Stem Cell Laboratory

Post Doctoral Research Associates

Dimitris Panutsopulos

The Neural Crest Cells can be subdivided in four distinct populations: cranial, cardiac, vagal and trunk. Cardiac neural crest cells migrate into the heart through the outflow tract and the inflow tract. Once will invade these points give rise to parasympathetic cardiac ganglia, the tunica media of the great vessels (smooth muscle layers), conotruncal cushions and the aorticopulmonary septum component of the outflow tract of the heart. My interest is to understand mechanisms and identify factors that influence the migration of the cardiac neural crest cells and the development of the conotruncal cushions and the aorti-copulmonary septum component in mice using mouse models

 

Alexandra Patmanidi

Research Interests: The hematopoietic cell lineage hierarchy is one of the best established models for developmental studies. We are using conditional knockout mice in order to study the impact of Geminin deletion from the early lineages of the hematopoietic compartment in subsequent cell fate decisions. As Geminin seems to regulate cell commitment programs of various blood cell lineages, we use transcriptional analyses in conjunction with genome-wide epigenetic techniques in order to understand the role of Geminin in the developing hematopoietic compartment. 

Advanced Light Microscopy Facility: Under the supervision of Professor Taraviras, I am also responsible for the Advanced Light Microscopy Facility at the Medical School of the University of Patras. The Facility provides access to confocal and fluorescence microscopes, training in basic and advanced methods for functional imaging (FRET, FRAP, FLIM, etc), as well as consultancy services. 


 

Doctoral Students

Spyridon Champeris  Tsaniras

Spyridon Champeris Tsaniras obtained his BSc from the department of Biomedical Sciences at King's College London, University of London. He performed his final year project on the in vitro differentiation of mouse embryonic stem (ES) cells towards pancreatic beta cells. During his MSc project in the same university, he continued his initial research project, further focusing on extracellular cues regulating differentiation along the pancreatic route. As a PhD candidate in Prof. Taraviras' lab, he is investigating the role the DNA replication licensing factors Geminin and Cdt1 play in carcinogenesis. To this end, he is working with mouse models of lung, colon and haematopoietic cancers as well as cancer stem cells. 

Argiro Kalogeropoulou

Argiro graduated from the Department of Biochemistry and Biotechnology at University of Thessaly, Greece, in 2011. She completed her MSc in Biomedicine at Uppsala University, Sweden, where she focused on the study of neuropeptides that regulate food consumption and metabolism.  Currently, she is pursuing her PhD in Dr. Taraviras' group and she investigates the molecular mechanisms that underlie the differentiation of neural stem cells towards cortical neurons. Specifically, she focuses on the role of Geminin during early- and mid- neurogenesis with respect to epigenetic and cell cycle regulation. Towards that direction Argiro works with mouse animal models, as well as with in vitro systems like primary cultures of neural stem cells.

 Marialena Lalioti

 Maria-Eleni graduated from the Department of Biology of the University of Patras in 2012. During her final year she performed her Diploma thesis under the supervision of Prof. Taraviras and her work was focused on the role of Geminin in the cell cycle profile of the enteric neural crest cells. In 2014 she obtained her MSc in the Basic Medical Sciences program at the Medical School of the University of Patras. Her thesis was carried out in Prof. Taraviras’ lab and it was about the implication Geminin in the proliferation capacity of the adult neural stem cells in the subependymal zone, the largest neurogenic niche in the adult rodent brain. She is currently a PhD candidate in Prof. Taraviras’ lab and her research is focused on understanding the mechanisms that control the lineage progression of radial glial cells towards ependymal and adult neural stem cells, the two main cellular components of the subependymal zone.

  

MSc Students

Konstantina Kaplani

Konstantina graduated from the Department of Biology of the University of Patras in 2015. She conducted her Diploma Thesis in Dr Taraviras’ Group, where she focused her work on the role of protein Geminin in the differentiation of neural stem cells in the subependymal zone of adult rodents towards neuroblasts. At the moment, she is attending her first year in the postgraduate study programme "Basic Medical Sciences" of the Medical School, aiming to specialize in the field of Stem Cells & Regenerative Medicine.

 

 

Stamatina Koutsi

Stamatina received her Bachelor's Degree in Pharmacy from the Department of Pharmacy of the University of Patras in 2015, where she also carried out her Bachelor diploma thesis in the field of Molecular Pharmacology. She is currently enrolled in the postgraduate study programme in "Basic Medical Sciences" of the Medical School of the University of Patras following the specialization ''Stem Cells & Regenerative Medicine'' and she is carrying out her master thesis in Prof. Stavros Taraviras laboratory.

 

 

Paraskevi Tserou
 

Paraskevi graduated from the Department of Biotechnology of Agricultural University of Athens in 2014. During her studies she carried out her Bachelor diploma thesis in the field of Plant Molecular Biology. Currently, Paraskevi is a Master student in "Biomedical Sciences" post graduate  programme at  the Medical School of the University of Patras, specializing in the fleld of "Regenerative Medicine & Stem Cells".  She is carring out her Master thesis in Prof. Stavros Taraviras laboratory, studying DNA replication dynamics and her research is focused on DNA replication fibers in cells that operate in the absence of geminin.  Contact her at: euhtserou[at]yahoo[dot]gr

Maria Villiou

Maria obtained her basic degree in the departement of Chemistry at Aristotle University of Thessaloniki in 2014, where she also carried out her Bachelor diploma thesis in the field of Organic Synthesis, Biochemistry & Bioapplications. She is currently a MSc student in “Biomedical Sciences” post graduate program at the Medical School of the University of Patras, aiming to specialize in the field of Stem Cells & Regenerative Medicine. Currently, she is working in Prof. Stavros Taraviras laboratory where her scientific project concerns the role of Geminin in colon cancer induction and in cancer intestinal stem cells. Contact her at: mavilliou[at]gmail[dot]com

 

Konstantina- Maria Founta

Konstantina graduated from the Department of Biology of the University of Patras in 2014, where she also carried out her Bachelor diploma thesis in the field of Physiology. Afterwards, she was admitted to the to the post graduate program "Basic Medical Sciences" of the Medical School of the University of Patras, aiming to specialize in the field of Stem Cells & Regenerative Medicine. Currently, she is carrying out her master thesis in the lab of Prof. Stavros Taraviras, where she is studying the role of Idas and Lynkeas in the radial glial cells' commitment and differentiation to ependymal cells. Contact her at: biokonna1991[at]gmail[dot]com

 

 Thodoris Kalliakoudas

 
Thodoris Kalliakoudas graduated from the Department of Biology of the University of Patras in 2014. He is currently MSc student in Basic Medical Sciences master program at the Medical School of the University of Patras. He is working in Prof. Stavros Taraviras laboratory where his scientific project concerns the role of Geminin in kinetics of MCM2-7 proteins in Neural Stem cells.