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 Our group research is focused on understanding how regulatory mechanisms acting at the level of cell cycle regulation, transcriptional control and chromatin organization are intergraded in order to achieve stem/progenitor cell maintenance and commitment/differentiation and how deregulation of these processes leads to human disease like cancer and neurodegeneration.


Towards this direction we are studying the role of Geminin, a gene involved in the regulation of proliferation and cellular differentiation through interactions with regulators of DNA replication origin licensing, transcription factors and chromatin modifying complexes. Based on our previous experience and tools and reagents already generated, we are using conditional knock mice, stem cell cultures and high-throuput approaches to study the role of Geminin in the regulation of self-renewal and fate commitment/differentiation decisions stem and progenitor cells